RESEARCH
ARTICLES
A critical factor facilitating metastasis is NETosis, the suicidal death of neutrophils.
How cannabis based medicines resolve this.
This process, a type of lytic cell death, results in the destruction of neutrophils and the release of neutrophil extracellular traps (NETs), which are rich in DNA and proteolytic enzymes.
While components of the NET network may initially contribute to the elimination of cancer cells, chronic inflammation and excessive neutrophil activation in tumor microenvironment can lead to detrimental effects.
NETs can facilitate the degradation of the extracellular matrix, thereby supporting the extravasation and transport of circulating tumor cells (CTCs). In addition, NETs can trap and anchor these cells at distant sites, thereby promoting metastasi
​
Phytocannabinoids, together with the endocannabinoid system (ECS), represent a highly promising therapeutic avenue for attenuating neutrophil effector functions, particularly the process of NETosis.
Its believed that these compounds have significant potential as agents capable of effectively inhibiting metastatic progression.
Phytocannabinoids, derived primarily from the Cannabis sativa plant, are a group of organic compounds that interact with the endocannabinoid system (ECS) in the human body.
The ECS, which includes CB1R and CB2R receptors, their agonists and antagonists, and enzymes responsible for the synthesis and degradation of ligands, is closely related to the action of phytocannabinoids .
​
The effects of phytocannabinoids and the ECS on neutrophil effector functions, particularly NETosis, are not yet fully understood. However, there are compelling, albeit limited, data suggesting that these compounds can inhibit the release of neutrophil extracellular traps in various disease models.
​
This inhibitory effect has not been thoroughly investigated in the context of cancer and its microenvironment.
That said many people in this research as well as prescribers will understand this and first hand seen the effects of cannabis based medicines.
​
Reference Link [1]
Research, Articles and Presentations by Dr Sunny Nayee
Abelev, Sarah & Warne, Leon & Benson, Melissa & Hardy, Mark & Nayee, Sunny & Barlow, John. (2022). Medicinal Cannabis for the Treatment of Chronic Refractory Pain: An Investigation of the Adverse Event Profile and Health-Related Quality of Life Impact of an Oral Formulation. Medical Cannabis and Cannabinoids. 5. 1-12. 10.1159/000521492. Reference Link [1] Reference Link [2]
​​
Intraoperative anaesthetic handover: an audit of the efficacy of a structured handover, RCOA Safe Anaesthesia Liaison Group Newsletter (December 2011).
Ace medicine. Finals Revision Guide. August 2008.
Dietary zinc intake and brain cancer in adults. British Journal of Nutrition. 2007 Oct 2;1-7.
Elderly Americans at risk to falls. Journal of Epidemiology and Health (critique) 2005;59:340.
Dietary zinc intake and primary adult brain tumour risk. Journal of Epidemiology and Community Health 2005;59(suppl_1):ii-v.
Zinc intake and glioma risk: international oral presentation – International Society for Social Medicine (Glasgow, 2005).
Improving handover safety: National Patient Safety Conference, Leicester (October, 2011). Audience of clinicians, hospital executive/board members, clinical governance managers, patient safety stakeholders.
Micronutrient Intake and Brain Cancer Risk: national oral poster presentation at the Environmental Health Conference (London, 2005).
National Research Oral Presentation Prize – Royal Society of Medicine (London, 2005).